Platelet Rich Fibrin

Leukocyte- and platelet-rich fibrin (L-PRF or PRF)  (PRF) is derived from the patient’s blood and consists of a natural complex fibrin matrix that is rich in platelets, growth factors and signaling proteins. These are derived from the patient’s blood platelets and white blood cells. L-PRF is known to accelerate the wound healing of soft (Gums) and hard tissue (Bone). The presence of these cells and proteins has been reported to produce rapid healing, especially during the first few weeks after surgery.

Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and a large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 ccs of blood, which is drawn from the patient while they are having outpatient surgery.


PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including the formation of a blood clot and the release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor-beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, PRF permits the body to heal faster and more efficiently.

A subfamily of TGF is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.


PRF can be mixed with bone particulates to help with bone regeneration in both periodontal and implant therapy. It is being used successfully to repair oral bone defects, sinus bone grafts and implant surgery.

To obtain PRF, a small amount of blood will be drawn quickly into test tubes chair-side and will be centrifuged immediately. The PRF will be ready to be utilized during the surgery in a matter of only 12 minutes.

Not only the PRF is used in dentistry, it is widely used in medical field. PRF is used for the treatment of surgical wounds, skin ulcers, facial soft-tissue defects, rotator cuff tears, orthopedic surgery, knee osteoarthritis, plastic surgery, acne scars and more.

PRF is a great choice for any surgery that you are having at the Ueno Center Dental Specialists. Not only does it speed healing and make your procedure more successful, it can also reduce swelling and pain after surgery. We recommend PRF for almost all gum grafting, bone grafting and implant procedures!


  • Safety: PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.
  • Convenience: PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.
  • Faster healing: The supersaturation of the wound with PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.
  • Cost-effectiveness: Since PRF harvesting is done with only 55 ccs of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in a hospital or at a blood bank.
  • Ease of use: PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.
For additional information about Platelet Rich Fibrin or to schedule an appointment with Dr. Ueno, Dr. Chung, Dr. Litch and Dr. Bui, please contact us our Campbell CA office at Ueno Dental Center Phone Number 408-371-7616 or


Is PRF safe? Yes. During the outpatient surgical procedure, a small amount of your own blood is drawn out via the IV. This blood is then placed in the PRF centrifuge machine and spun down. In less than 15 minutes, the PRF is formed and ready to use.

Should PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for PRF. However, in the majority of cases, the application of PRF to the bone graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the PRF application (approximately $550) is paid by the patient.

Can PRF be used alone to stimulate bone formation? No. PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRF is right for you.